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Plasma thrombin-antithrombin complex as a candidate biomarker for coronary slow flow
Jian-Hong Mo1, Bo Liang2, Jing-Tao Cen1
1Department of Cardiology, the People's Hospital of Fengkai County, Zhaoqing, Guangdong, China.
Insights
Elevated thrombin-antithrombin (TAT) complex levels are linked to coronary slow flow (CSF), a condition challenging to diagnose. TAT may serve as a potential biomarker for identifying this coronary artery issue.
Area of Science:
- Cardiology
- Biochemistry
- Diagnostic Biomarkers
Background:
- Coronary slow flow (CSF) presents diagnostic challenges due to unclear pathophysiology.
- CSF is defined by delayed coronary perfusion without significant stenosis.
Purpose of the Study:
- To investigate the association between thrombin-antithrombin (TAT) complex levels and CSF.
- To evaluate TAT as a potential diagnostic biomarker for CSF.
Main Methods:
- Retrospective cohort study including 91 CSF patients and 74 controls.
- Coronary blood flow assessed using thrombolysis in myocardial infarction frame count (TFC).
- Plasma TAT complex levels measured via chemiluminescent immunoassay; logistic regression and ROC analysis performed.
Main Results:
- CSF patients exhibited higher plasma TAT complex, total cholesterol, and LDL cholesterol levels.
- Multivariate analysis identified TAT as an independent predictor of CSF (OR: 1.71, p < 0.001).
- ROC analysis indicated a TAT level of 3.875 ng/ml predicted CSF with 89.2% specificity and 62.6% sensitivity.
Conclusions:
- Elevated plasma TAT complex levels are significantly associated with coronary slow flow.
- TAT complex shows potential as a candidate diagnostic biomarker for CSF.
Background:
Coronary slow flow (CSF), characterized by delayed coronary perfusion without significant coronary artery stenosis, remains a diagnostic challenge due to its elusive pathophysiology. This retrospective study aimed to evaluate the association between the thrombin-antithrombin (TAT) complex and CSF.
Patients And Methods:
Ninety-one CSF patients and 74 subjects with normal coronary flow were recruited in this cohort. Coronary artery blood flow was quantified using the thrombolysis in myocardial infarction frame count (TFC) method. Plasma TAT complex levels were measured via chemiluminescent immunoassay. Logistic regression analyses and a receiver operating characteristic (ROC) curve were performed to determine the predictive value of TAT for CSF.
Results:
Compared with patients without CSF, patients with CSF showed higher plasma levels of TAT complex, total cholesterol, and low-density lipoprotein cholesterol, all of which were also positively correlated with TFC. However, multivariate logistic regression identified TAT as the only independent predictor of CSF after adjustment (OR: 1.71, 95% CI: 1.39-2.10, p < 0.001). More specifically, ROC analysis revealed that a plasma TAT complex levels of 3.875 ng/ml predicted CSF with a specificity of 89.2% and a sensitivity of 62.6%.
Conclusion:
Elevated plasma TAT complex levels are strongly associated with CSF and may serve as a candidate diagnostic biomarker.
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