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Updated: Sep 13, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Zirconium-Catalyzed Reductive Sulfonamidation of Amides and Its Application to Site-Selective N‑Alkylation of
Abhishek Raj1, Weiheng Huang1, Chabush Haldar1
1Department of Chemistry and Biochemistry, Baylor University, Waco, Texas 76706, United States.
Abstract:
The direct catalytic reductive amination of amides remains a challenging transformation, particularly when using weakly nucleophilic amines. However, this strategy offers several synthetic advantages, particularly due to the wide availability of amides, as well as N-sulfonyl and N-sulfinyl amines. We present a mild catalytic approach for the monoalkylation of sulfonamides, sulfamates, sulfamides, and sulfinamides using amides. This protocol exploits the oxophilic character of zirconium, an early, earth-abundant metal, to drive dual reductive cycles and enable the critical amination step. This chemistry is carried out at room temperature using just 10 mol % of Cp2ZrCl2 in combination with hydrosilane reductant, yielding products in up to 94% isolated yield with excellent selectivity. This chemistry enables site-selective monoalkylation of sulfonamides, including examples of late-stage N-alkylation in pharmaceutical applications.
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