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Step-Down Therapy Using Vonoprazan for Giant Gastric Polyps in Long-Term Proton Pump Inhibitor Administration

Daisuke Kikuchi1, Yorinari Ochiai2, Yoshio Hoshihara2

  • 1Department of Gastroenterology, Toranomon Hospital Kajigaya, Kawasaki, Japan.

Case Reports in Gastroenterology
|July 30, 2025
PubMed
Summary

Minimal acid suppression therapy using vonoprazan effectively controlled gastroesophageal reflux disease (GERD) symptoms and significantly shrank gastric polyps in a long-term proton pump inhibitor (PPI) user. This step-down approach offers a potential alternative for managing GERD and associated polyps.

Keywords:
Patient-reported outcomeProton pump inhibitorReflux esophagitisStep-down therapyVonoprazan

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