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TRIM21: a multifaceted regulator in cancer.
Aizhuo Li1, Jiannan Wang1, Yi Qu2
1Department of Ultrasound, The First Affiliated Hospital of China Medical University, Shenyang, China.
Frontiers in Cell and Developmental Biology
|July 30, 2025
Summary
Tripartite motif-containing 21 (TRIM21) is an E3 ubiquitin ligase crucial for regulating cell signaling and tumor progression. Understanding TRIM21
Area of Science:
- Biochemistry and Molecular Biology
- Oncology
- Cellular Biology
Background:
- Ubiquitination is a key post-translational modification regulating cellular processes.
- Tripartite motif-containing 21 (TRIM21) is an E3 ubiquitin ligase involved in various cellular functions.
- TRIM21 plays a significant role in tumorigenesis and development by modifying substrate proteins.
Purpose of the Study:
- To provide an in-depth understanding of TRIM21's mechanisms in biological processes and cancer.
- To explore TRIM21's multifaceted roles in autophagy, metabolism, immune evasion, proliferation, metastasis, and cell death resistance.
- To highlight the potential of TRIM21 as a therapeutic target for novel cancer treatments.
Main Methods:
- This review synthesizes existing research on TRIM21.
- Literature analysis of TRIM21's function in various biological contexts.
- Examination of TRIM21's role in different tumor types and associated signaling pathways.
Main Results:
- TRIM21 regulates protein stability and function, impacting key cellular pathways.
- TRIM21 is implicated in diverse cancer-related processes including immune escape and metastasis.
- TRIM21's activity is critical for tumor proliferation and resistance to cell death.
Conclusions:
- TRIM21 is a pivotal regulator in tumorigenesis and development.
- Targeting TRIM21 offers potential for developing novel therapeutic strategies.
- Further research into TRIM21 mechanisms can advance cancer treatment options.
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