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Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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Reticular Dermis01:15

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Layers of the Epidermis01:21

Layers of the Epidermis

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The epidermis, the outermost layer of the skin, is composed of several distinct layers. From deep to superficial, the layers of the epidermis are as follows:
Stratum Basale
Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...
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Cells of the Epidermis01:24

Cells of the Epidermis

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The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
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Updated: Sep 13, 2025

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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A Typical Dermoscopic Pattern of PLEVA.

Mahesh Mathur1, Sumit Paudel1, Supriya Paudel1

  • 1Department of Dermatology, College of Medical Sciences Teaching Hospital Bharatpur Nepal.

Clinical Case Reports
|July 30, 2025
PubMed
Summary
This summary is machine-generated.

Pityriasis lichenoides et varioliformis acuta (PLEVA) diagnosis is aided by a novel dermoscopic pattern. This non-invasive method offers advantages over traditional skin biopsies for identifying this benign inflammatory condition.

Keywords:
PLEVAcentral crustdermoscopytargetoid patternvascular structureswhite scales

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Area of Science:

  • Dermatology
  • Dermatopathology

Background:

  • Pityriasis lichenoides et varioliformis acuta (PLEVA) is a benign inflammatory skin condition.
  • Accurate diagnosis is crucial for appropriate patient management.
  • Current diagnostic methods can be invasive or lack specificity.

Purpose of the Study:

  • To introduce and describe a novel dermoscopic pattern observed in PLEVA.
  • To evaluate the utility of this dermoscopic pattern in diagnosing PLEVA.
  • To compare the diagnostic value of dermoscopy with skin biopsy for PLEVA.

Main Methods:

  • Dermoscopic examination of patients diagnosed with PLEVA.
  • Identification and characterization of a distinct dermoscopic pattern.
  • Comparison of dermoscopic findings with histopathological results from skin biopsies.

Main Results:

  • A specific, new dermoscopic pattern was identified in PLEVA cases.
  • This pattern demonstrates high diagnostic accuracy for PLEVA.
  • Dermoscopy provides distinct features, whereas skin biopsy shows non-specific inflammatory changes.

Conclusions:

  • The novel dermoscopic pattern is a valuable tool for diagnosing PLEVA.
  • Dermoscopy offers a non-invasive and specific alternative to skin biopsy for PLEVA diagnosis.
  • This finding can improve the diagnostic workflow for PLEVA.