Related Experiment Video
Updated: Sep 13, 2025
01:37
A Preterm Rat Model for Pain Studies
Published on: February 9, 2024
490
Congenital Insensitivity to Pain With Anhidrosis: First Reported Case in Nepal.
Sobin Pant1, Dibij Adhikari1, Prakash Pandey1
1Maharajgunj Medical Campus, Institute of Medicine Tribhuvan University Kathmandu Nepal.
Clinical Case Reports
|July 30, 2025
Summary
Congenital insensitivity to pain with anhidrosis (CIPA) is a rare genetic disorder. Early clinical recognition and multidisciplinary care are vital for preventing severe complications in affected individuals.
Area of Science:
- Genetics
- Neurology
- Pediatrics
Background:
- Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive disorder.
- Characterized by anhidrosis, self-mutilation, and impaired pain/temperature sensation.
- Clinical recognition is crucial, especially where genetic testing is unavailable.
Purpose of the Study:
- To highlight the importance of clinical recognition of CIPA.
- To emphasize the need for early diagnosis and management.
- To outline strategies for preventing complications.
Main Methods:
- Review of clinical characteristics of CIPA.
- Discussion of diagnostic challenges in resource-limited settings.
- Emphasis on multidisciplinary care approaches.
Main Results:
- CIPA presents with a distinct triad of symptoms.
- Genetic confirmation may not always be feasible.
- Prompt diagnosis prevents severe injuries and hyperpyrexia.
Conclusions:
- Early clinical diagnosis of CIPA is critical.
- A multidisciplinary approach is essential for comprehensive patient care.
- Timely intervention significantly reduces morbidity and mortality.
Keywords:
anhidrosiscongenital insensitivity to pain with anhidrosishereditary sensory and autonomic neuropathy type IVpain insensitivityresource‐limited settingsself‐mutilationMore Related Videos
Related Concept Videos
01:25Analgesia and Pain Management
803
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
803
01:20Pain
631
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
631
01:44Nociception
29.5K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
29.5K
01:24Local Anesthetics: Differential Sensitivity of Nerve Fibers
935
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
935
01:43Thermosensation
31.8K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
31.8K