Aging of the Human Lip: Current Knowledge and Clinical Implications
Fanghui Sun1, Yue Liu1, Tao Zhang1
1R&D Center, Better Way (Shanghai) Cosmetics Co., Ltd, Shanghai, People's Republic of China.
Journal of Cosmetic Dermatology
|July 30, 2025
Summary
Lip aging differs from facial aging due to unique anatomical and physiological characteristics. Developing targeted anti-aging lip products requires distinct strategies focusing on barrier repair and addressing gender-specific concerns.
Area of Science:
- Dermatology
- Cosmetic Science
- Aging Research
Background:
- Lip aging research is limited by anatomical complexity.
- Current focus is on dryness, cheilitis, and surgical interventions.
- Comprehensive understanding of lip aging is needed.
Purpose of the Study:
- Review diverse aspects of lip aging.
- Explore novel anti-aging strategies for lips.
- Inform cosmetic lip care product development.
Main Methods:
- Conducted a literature search in PubMed.
- Utilized keywords related to lip aging.
- Selected and integrated relevant articles for review.
Main Results:
- Lips exhibit unique aging due to differences in barrier function, melanin, absorption, activity, and fat.
- Gender influences lip aging, with women showing more perioral wrinkles.
- Lip aging characteristics are distinct from facial skin aging.
Conclusions:
- Lip aging requires distinct anti-aging priorities compared to facial aging.
- Vermilion aging needs barrier restoration, mild treatments, and photoaging prevention.
- Perioral aging can be targeted by inhibiting ECM degradation and enhancing volume, with consideration for gender-specific needs.
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