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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Related Experiment Video

Updated: May 11, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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Polymeric Microneedles: Advancing Potential Through Innovative Manufacturing, Polymer Design, and Characterization

Caroline Lamie1,2, Athina-Myrto Chioni3, Natividad Garrido-Mesa1

  • 1Drug Discovery, Delivery and Patient Care (DDDPC), School of Life Sciences, Pharmacy and Chemistry, Kingston University London, Kingston Upon Thames, Surrey, KT1 2EE, UK.

Current Pharmaceutical Design
|July 30, 2025
PubMed
Summary
This summary is machine-generated.

Polymeric microneedles (MNs) offer a minimally invasive alternative for drug delivery, improving patient adherence and treatment effectiveness. This review details their fabrication, polymer selection, and characterization for enhanced transdermal administration.

Keywords:
Polymeric microneedlescharacterization techniquesmanufacturing techniquesmicromoldingterpenestransdermal delivery

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Area of Science:

  • Pharmaceutics and Biomedical Engineering
  • Materials Science

Background:

  • Microneedles (MNs) offer a minimally invasive alternative to traditional drug delivery methods like injections and oral administration.
  • Conventional methods often lead to patient discomfort, poor adherence, and reduced therapeutic efficacy.
  • Polymeric MNs present a promising solution for transdermal drug delivery, enhancing patient compliance.

Purpose of the Study:

  • To provide a comprehensive review of polymeric microneedles (MNs) in drug delivery.
  • To analyze fabrication techniques, polymer selection, and pharmaceutical characterization of MNs.
  • To highlight advancements and potential applications of polymeric MNs in revolutionizing therapeutic interventions.

Main Methods:

  • Review of current literature on polymeric microneedle technology.
  • Analysis of fabrication methods, including advancements in manufacturing approaches.
  • Evaluation of polymer selection criteria, focusing on biocompatibility and biodegradability.
  • Assessment of pharmaceutical characterization techniques for drug solubility, stability, and controlled release.

Main Results:

  • Polymeric MNs enable effective transdermal drug administration, improving drug solubility, stability, and controlled release.
  • Biocompatible and biodegradable polymers are crucial for optimizing MN performance.
  • Various fabrication techniques are available, with ongoing advancements in manufacturing.
  • Polymeric MNs show potential for diverse medical applications, enhancing therapeutic outcomes.

Conclusions:

  • Polymeric microneedles represent a significant advancement in drug delivery technology.
  • Their minimally invasive nature and improved efficacy position them as a cornerstone for next-generation therapeutics.
  • Continued innovation in polymeric MNs promises substantial improvements in patient care and treatment outcomes.