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Updated: Sep 13, 2025

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids
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Rare systemic skin hyperpigmentation associated with osimertinib: A case report

Le Li, Lifang Yang, Guanglei Xu

    International Journal of Clinical Pharmacology and Therapeutics
    |July 30, 2025
    PubMed

    Insights

    A rare case of severe skin hyperpigmentation occurred in a patient undergoing osimertinib treatment for advanced small cell lung cancer. Clinicians should be aware of this adverse drug reaction for patient safety.

    Area of Science:

    • Oncology
    • Dermatology
    • Pharmacology

    Background:

    • Small cell lung cancer (SCLC) is a challenging diagnosis.
    • Osimertinib is a targeted therapy used in cancer treatment.
    • Severe skin adverse reactions, like hyperpigmentation, can occur during cancer therapy.

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