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Updated: Sep 13, 2025

Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing
Published on: February 10, 2023
Digest: Sex-specific benefits of mitochondrial introgression
1Department of Genetics, Evolution and Environment, University College London, London, United Kingdom.
Abstract:
Disrupting mitochondrial and nuclear co-adaptation is expected to reduce fitness, especially in males and with age. But is that always true? Garlovsky et al. (2025) tested this in a panel of Drosophila lines, assessing reproductive success across sex and age. Unexpectedly, new mitonuclear combinations had limited impact on reproduction and even conferred a fitness advantage to some males. These findings challenge current views, suggesting that mitochondrial replacement can sometimes enhance fitness.
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