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Updated: Sep 13, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Medical knowledge decline: the role of active usage
Yunting Liu1,2, Yanlin Jiang3, Andrew D Dallas3
1Berkeley School of Education, University of California, Berkeley, CA, USA. yunting99@berkeley.edu.
None:
This paper details the reason for the decline in medical knowledge after initial certification of physician assistants/associates (PAs) and suggests improvement in competency assessment after initial certification. We hypothesized that the decline was caused by less frequency of use; in other words, knowledge retention was impacted by the active use of knowledge. If so, the likelihood of a decline in knowledge is mediated by the closeness of the test content to the practitioners' daily practice. Data from Physician Assistants (PA) initial certification (PANCE) and re-certification (PANRE-LA, after 6 years) were used for the current study. To quantify the level of active usage, knowledge subdomains were classified into three categories for each medical specialty: dominant, relevant and distant, ranging from the most frequently used to the least used knowledge, which was verified by four independent board-certified PAs with clinical and educational experience. To test the hypothesis, Latent transition analysis (LTA) is used to measure the probability of transitions among behavioral patterns over time, in particular how various levels of transition probabilities (e.g., probability from proficient switching to non-proficient) are related to the frequency of use. We found that the trends of knowledge decline are influenced by practice profile (medical specialty), mainly, knowledge active in daily use (i.e., dominant knowledge) over time- the less frequent the knowledge is used, the more likely the knowledge decline will take place. In particular, compared to dominant knowledge (i.e., most frequently used knowledge), relevant knowledge (i.e., mediumly frequent used knowledge) and distant knowledge (i.e., rarely used knowledge) are more likely to decline (OR = 2.31, CI = [1.82, 2.94], p < 0.001; OR = 2.26, CI = [1.84, 2.78], p < 0.001). Moreover, dominant system knowledge has a better chance to improve over the years as compared to relevant and distant system knowledge (OR = 2.19, CI = [1.71, 2.81], p < 0.001; OR = 2.12, CI = [1.72, 2.65], p < 0.001). Instead of a uniform knowledge decay, medical practitioners suffer from a differential likelihood of knowledge decay over different systems knowledge. Implications for re-certification exams are discussed.
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