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Updated: Sep 13, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Medical knowledge decline: the role of active usage.
Yunting Liu1,2, Yanlin Jiang3, Andrew D Dallas3
1Berkeley School of Education, University of California, Berkeley, CA, USA. yunting99@berkeley.edu.
Physician knowledge decline is linked to how often it's used in practice. Less frequently used medical knowledge, like that in physician assistant (PA) re-certification exams, decays faster, impacting patient care.
Area of Science:
- Medical Education
- Continuing Professional Development
- Health Professions
Background:
- Physician assistants/associates (PAs) experience a decline in medical knowledge after initial certification.
- This decline may be linked to the frequency of knowledge application in daily clinical practice.
- Understanding knowledge retention patterns is crucial for effective continuing medical education and recertification.
Purpose of the Study:
- To investigate the reasons behind the decline in PA medical knowledge post-certification.
- To determine if the frequency of knowledge use in practice influences knowledge retention.
- To inform improvements in competency assessment and recertification strategies for PAs.
Main Methods:
- Analysis of data from Physician Assistant National Certifying Exam (PANCE) and Physician Assistant National Recertifying Exam – Longitudinal Assessment (PANRE-LA).
- Classification of medical knowledge subdomains into 'dominant', 'relevant', and 'distant' based on frequency of use, verified by expert PAs.
- Latent Transition Analysis (LTA) to model knowledge decay probabilities in relation to usage frequency.
Main Results:
- Knowledge decline is significantly influenced by practice profile and frequency of use.
- Less frequently used knowledge ('relevant' and 'distant') showed a higher likelihood of decline compared to 'dominant' knowledge (OR=2.31 and OR=2.26, respectively).
- Dominant knowledge demonstrated a greater probability of improvement over time compared to relevant and distant knowledge.
Conclusions:
- Medical knowledge decay is not uniform; it varies based on the specific knowledge domain and its clinical relevance.
- Recertification assessments should consider the differential decay rates of medical knowledge based on usage frequency.
- Tailoring continuing education and assessment strategies to address specific knowledge gaps can enhance PA competency maintenance.
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