Related Experiment Video

Updated: Sep 8, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

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Androgen receptor as a potential therapeutic target in castration-resistant prostate cancer: a bibliometric analysis

Jiexiang Zhang1,2,3,4, Weichen Yuan5,6, Tongtong Zhang1,2,3,4

  • 1Urology Centre, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.

Discover Oncology
|July 30, 2025
PubMed
Abstract

Insights

This bibliometric analysis of castration-resistant prostate cancer (CRPC) and androgen receptor (AR) research reveals key trends and emerging frontiers. Findings guide future AR-targeted therapies for CRPC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Bibliometrics

Background:

  • Androgen receptor (AR) is a critical target in castration-resistant prostate cancer (CRPC).
  • Recent research offers insights for advancing AR-targeted therapies.
  • This study analyzes CRPC and AR research trends.

Purpose of the Study:

  • To comprehensively analyze research trends in CRPC and AR fields.
  • To identify emerging hotspots and future research directions.
  • To provide strategic insights for future AR-targeted therapeutic development.

Main Methods:

  • Bibliometric analysis of 3,149 publications (2005-2024) from Web of Science Core Collection.
  • Data visualization using VOSviewer, CiteSpace, and R package 'Bibliometrix'.
  • Analysis of author contributions, institutional output, journal impact, and keyword trends.

Main Results:

  • Rapid publication growth observed over two decades, with the US as the leading contributor.
  • Key research areas include AR splice variants and CRPC drug resistance.
  • Emerging focus on novel membrane antigens indicates current research frontiers.

Conclusions:

  • The study maps the evolving knowledge landscape in CRPC and AR research.
  • Identifies shifting research priorities and key influential works.
  • Offers strategic guidance for developing future AR-targeted therapies for CRPC.
Keywords:
Androgen receptorBibliometricsCastration-resistant prostate cancerWeb of science

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