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Androgen stimulation and laryngeal development.

N S Beckford, S R Rood, D Schaid

The Annals of Otology, Rhinology, and Laryngology

|November 1, 1985

Summary

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Androgens significantly influence laryngeal growth in sheep. Testosterone and dihydrotestosterone treatments altered thyroid horn separation and other laryngeal dimensions, indicating dose-dependent effects.

Area of Science:

Endocrinology
Comparative Anatomy
Developmental Biology

Background:

Androgens play a crucial role in sexual dimorphism and development.
Laryngeal growth is a key component of vocalization and sexual maturation.

Purpose of the Study:

To investigate the specific effects of androgens on laryngeal growth patterns.
To establish dose-response relationships for testosterone and dihydrotestosterone on laryngeal morphology.

Main Methods:

Utilized a sheep model with 48 lambs divided into eight treatment groups.
Administered varying doses of testosterone and dihydrotestosterone to castrated lambs.
Performed gross dissections and obtained 34 linear and angular measurements of the larynx.

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Main Results:

Superior thyroid horn separation exhibited the most significant androgen-induced change (p = 0.023).
Positive dose-response relationships were observed for laryngeal anterior-posterior diameter, superior thyroid horn height, and other key laryngeal measurements.
Hypoandrogenism showed an inhibitory effect on laryngeal growth compared to castrated controls.

Conclusions:

Androgens are critical regulators of laryngeal development and morphology.
Specific laryngeal dimensions demonstrate clear dose-dependent responses to androgens.
Further research into androgen-mediated laryngeal development is warranted.