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Radiotherapy: Beyond cancer….

Nicolas Giraud1, Cécile Ortholan2, Magali Quivrin3

  • 1Radiation Oncology Department, hôpital Haut-Lévêque, CHU de Bordeaux, Pessac, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|July 30, 2025
PubMed
Summary
This summary is machine-generated.

Radiotherapy is now used for benign conditions like tumors and pain, offering precise, non-invasive treatments. This approach shows promise for improving patient outcomes and quality of life beyond cancer care.

Keywords:
BenignBéninFonctionnelFunctionalRadiotherapyRadiothérapie

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Medical Physics

Background:

  • Radiotherapy, traditionally a cancer treatment, is expanding to non-malignant conditions.
  • Advances in imaging and delivery techniques enable precise treatment of benign disorders.

Purpose of the Study:

  • To review the expanding applications of radiotherapy in non-cancer settings.
  • To synthesize current practices, technical aspects, and research findings.
  • To highlight the need for further trials and guidelines.

Main Methods:

  • Review of current clinical practices and technical considerations.
  • Synthesis of emerging results from prospective cohorts and multicentre registries.
  • Analysis of radiotherapy's efficacy in diverse benign and functional disorders.

Main Results:

  • Stereotactic radiosurgery effectively controls benign intracranial tumors and functional disorders.
  • Low-dose radiotherapy alleviates pain in osteoarticular conditions and tendinopathies.
  • Orbital irradiation and postoperative protocols show efficacy in Graves' orbitopathy and keloid prevention, respectively.

Conclusions:

  • Radiotherapy demonstrates consistent symptom relief and favorable safety profiles in non-cancer applications.
  • The findings support radiotherapy's expanded role in managing benign and functional disorders.
  • Further research and consensus guidelines are crucial for optimizing these treatments.