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Related Concept Videos

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
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Characterizing early auditory deficits in schizophrenia using drift-diffusion modeling.

Clément Dondé1, Michael Pereira2, Ladislas Nalborczyk3

  • 1Univ. Grenoble Alpes, F-38000 Grenoble, France; INSERM, U1216, Grenoble institute Neurosciences, F-38000 Grenoble, France; Adult Psychiatry Department, University Hospital Grenoble Alpes, F-38000 Grenoble, France; Adult Psychiatry Department, Centre Hospitalier Alpes-Isère, F-38000 Saint-Egrève, France.

Schizophrenia Research
|July 30, 2025
PubMed
Summary
This summary is machine-generated.

Schizophrenia patients show impaired tone-matching due to slower evidence accumulation and delayed responses, not just sensory issues. Computational modeling reveals deficits in translating sensory input into behavior.

Keywords:
Auditory processingComputational modelingDrift-diffusion modelResponse timeSchizophreniaTone-matching

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Area of Science:

  • Cognitive Neuroscience
  • Psychiatry

Background:

  • Tone-matching disturbances are common in schizophrenia.
  • The role of sensory processing versus behavioral translation in these deficits is unclear.

Purpose of the Study:

  • To deconstruct tone-matching deficits in schizophrenia using an evidence accumulation model.
  • To precisely characterize perceptual decision-making impairments in schizophrenia.

Main Methods:

  • 30 individuals with schizophrenia and 30 healthy controls performed a tone discrimination task.
  • Bayesian models analyzed accuracy and reaction times.
  • Drift Diffusion Model (DDM) quantified decision-making parameters.

Main Results:

  • Schizophrenia patients had lower accuracy and longer reaction times.
  • DDM showed slower evidence accumulation (drift rate) and increased non-decision time in schizophrenia.
  • No differences in starting point bias or boundary separation were found.

Conclusions:

  • Tone-matching impairments in schizophrenia stem from deficits in evidence accumulation and sensory-to-behavioral translation.
  • Computational modeling offers insights into the cognitive pathophysiology of schizophrenia.
  • This approach highlights mechanisms of perceptual and decisional deficits.