Postoperative survival evaluation of patients with Siewert II adenocarcinoma of esophagogastric junction: a population-based study

To explore the influencing factors of postoperative survival in Siewert II adenocarcinoma of esophagogastric junction (AEG).

The eligible patients and 28 variables were extracted from the Surveillance, Epidemiology, and End Results database. The association of each variable with overall survival (OS) was explored by univariable COX regression analysis. Multivariable COX analysis was then conducted to determine the independent factors. Kaplan-Meier method was used to compare the OS difference between 2 groups.

Totally 3568 patients were enrolled, of whom 2344 patients died. There were 23 variables showing the differences between alive and dead groups (all P ​< ​0.05). Univariable COX and LASSO regression analyses identified 7 key features associated with OS, including age, income, M stage, chemotherapy, systemic therapy plus surgical procedures, liver metastasis, and tumor size.

The M stage and tumor size were the key factors associated with postoperative survival of patients with Siewert II AEG.