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Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
Published on: October 3, 2014
Biomaterial scaffolds for therapeutic immune cell engineering and delivery
1Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin Madison, Madison, WI 53705, USA; Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA; Wisconsin Center for NanoBioSystems, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA; Institute for Clinical and Translational Research, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
None:
Cell-based therapeutics represent an emerging treatment modality for a variety of ailments and diseases. Adoptive cell therapies, including T cell therapies have demonstrated remarkable success in the treatment of cancers. With the demonstrated efficacy and successful navigation of regulatory hurdles by multiple cell therapies, researchers are looking to expand their application and increase their efficacy. However, these efforts are frequently hindered by the inherent complexity and unique challenges posed by cell therapies. These challenges include effective delivery to diseased tissues, engineering and maintaining therapeutic phenotypes, and prolonging cell viability among others. To overcome these obstacles and successfully implement cell therapies in the clinic, an emerging trend is to turn toward the use of biomaterial-based scaffolds. In this review, we will discuss the application of biomaterial scaffolds in the engineering, delivery, and recruitment of therapeutic immune cells.
