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Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
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Unveiling the link: aging and its impact on ocular diseases
Ke Wang1, Yifang Xie1, Yumeng Lin2
1Eye School of Chengdu University of Traditional Chinese Medicine, Deyang Hospital Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Deyang, China.
Experimental Eye Research
|July 30, 2025
Summary
Aging causes cellular decline, leading to eye diseases like cataracts and AMD. This review explores aging
Area of Science:
- Ophthalmology and Gerontology
- Cellular Biology and Aging
- Biomedical Science
Background:
- Aging is characterized by progressive structural and functional decline at the cellular level.
- Cellular senescence and metabolic imbalances (mitochondrial, glucose, lipid, fluid dynamics) contribute to age-related diseases.
- The eye's unique systems are susceptible to age-related cellular senescence, leading to diverse ocular pathologies.
Purpose of the Study:
- To elucidate the intricate relationship between the biological mechanisms of aging and the development of age-related eye diseases.
- To analyze anatomical and functional changes in the eye associated with the aging process.
- To review current and emerging therapeutic strategies for managing age-related ocular conditions.
Main Methods:
- Comprehensive literature review analyzing biological aging mechanisms and ocular anatomical changes.
- Examination of pharmacological interventions, including oral antioxidants, anti-VEGF therapies, and lutein supplementation.
- Evaluation of innovative therapeutic delivery systems, such as nanoparticle-based therapies and gene therapy.
Main Results:
- Aging-induced cellular dysfunction and metabolic imbalances are directly linked to the pathogenesis of various eye diseases.
- Established therapies like antioxidants and anti-VEGF agents, alongside nutritional support (lutein), show efficacy.
- Novel approaches including targeted drug delivery via nanoparticles and gene therapy for mitochondrial and lipid metabolism hold significant therapeutic potential.
Conclusions:
- Cellular senescence and metabolic dysregulation are key drivers of age-related eye diseases.
- A multi-faceted approach combining pharmacological treatments, advanced delivery systems, lifestyle modifications, and early screening is crucial.
- Continued research into optimizing novel therapies is essential for improving long-term outcomes in age-related vision impairment.
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