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Three new cyclopeptides from the Lycii cortex.

Pei-Pei Liang1, Ya-Di Duan1, Meng-Nan Zhou1

  • 1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, People's Republic of China.

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Summary
This summary is machine-generated.

Ten cyclopeptides were isolated from Lycii Cortex, including three new compounds. Compounds 7-9 demonstrated anti-inflammatory effects by inhibiting key inflammatory markers like IL-6 and TNF-α.

Keywords:
Anti-inflammatory activityChemical compositionCyclopeptidesLycii cortex

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Area of Science:

  • Natural Product Chemistry
  • Pharmacology

Background:

  • Lycii Cortex is a traditional medicinal plant.
  • Cyclopeptides are a class of natural products with diverse biological activities.

Purpose of the Study:

  • To isolate and identify cyclopeptides from Lycii Cortex.
  • To investigate the anti-inflammatory activity and mechanism of selected cyclopeptides.

Main Methods:

  • Extraction and isolation of compounds using 70% ethanol.
  • Identification using physical, chemical, and spectroscopic methods.
  • In vitro anti-inflammatory assays on LPS-induced RAW264.7 cells.

Main Results:

  • Ten cyclopeptides were identified, including three new cyclopeptides (1-3) and one new natural product (4).
  • Compounds 5 and 6 were isolated from this plant for the first time.
  • Compounds 7-9 exhibited anti-inflammatory activity by inhibiting interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) mRNA expression.
  • These compounds also reduced nitric oxide (NO), IL-6, and TNF-α secretion.

Conclusions:

  • Lycii Cortex is a rich source of cyclopeptides.
  • Compounds 7-9 possess significant anti-inflammatory properties.
  • The anti-inflammatory mechanism involves the inhibition of IL-6 and TNF-α pathways.