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Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
Published on: February 17, 2018
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The Cardiohepatic Axis in Heart Failure.
Arick C Park1, Joel D Schilling2
1Department of Internal Medicine, Washington University School of Medicine in St Louis, St. Louis, Missouri, USA.
JACC. Basic to Translational Science
|July 30, 2025
Summary
Cardiogenic liver disease, a consequence of heart failure, causes liver dysfunction. Further research is needed to understand the underlying mechanisms of liver fibrosis and dysfunction in heart failure patients.
Area of Science:
- Cardiology
- Hepatology
- Pathology
Background:
- Cardiogenic liver disease results from hepatic congestion due to right heart failure.
- It leads to hepatic dysfunction and liver remodeling.
- Understanding liver pathology in heart failure is crucial for patient care.
Purpose of the Study:
- To review current understanding of the cardiohepatic axis in heart failure.
- To highlight knowledge gaps in cardiogenic liver disease.
- To identify opportunities for future research.
Main Methods:
- Review of recent human and preclinical data.
- Analysis of cellular and molecular pathways involved in cardiogenic liver disease.
Main Results:
- Liver congestion triggers significant responses in hepatocytes and nonparenchymal cells.
- Pathways driving liver fibrosis and dysfunction remain poorly understood.
- Emerging data is beginning to elucidate the cellular and molecular landscape.
Conclusions:
- Cardiogenic liver disease is a complex condition requiring further investigation.
- Elucidating the mechanisms of liver fibrosis and dysfunction is essential.
- Future research should focus on the cardiohepatic axis to improve patient outcomes.
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