Association between Life's Essential 8 and hyperuricemia in the Chinese elderly

Life's Essential 8 (LE8) is a comprehensive indicator that evaluates cardiovascular health (CVH). There have been limited studies on the relationship between LE8 and hyperuricemia (HUA). This study explored the association and dose-response relationship between LE8 and HUA among elderly people in China.

The subjects were the elderly aged 60 and over who participated in the China Health and Nutrition Survey (CHNS) in 2018. The definition of American Heart Association (AHA) was used to measure the score of LE8. Multivariate Logistic regression and restricted cubic spline (RCS) model were used to analyze the association and dose-response relationship between LE8 and HUA.

A total of 4229 subjects were included, and the prevalence of HUA was 13.2%. The LE8 score was 68.5 points, and physical activity (85.8) and blood pressure (37.6) were the highest and lowest scores, respectively. People with low, medium and high CVH accounted for 5.7%, 77.3% and 17.0%, respectively. Multivariate Logistic regression showed that high CVH in LE8 score reduced the risk of HUA (OR = 0.62, 95%CI = 0.39-0.99) significantly, and the risk decreased by 15% (OR = 0.85, 95%CI = 0.78-0.93) for every 10-point increase in LE8 score. RCS showed a linear dose-response relationship between LE8 and HUA, and the beneficial protective threshold was 68.6 points. The negative association between LE8 score and HUA was more significant in 60-69 years.

This study suggested that the elderly in 15 provinces of China were at a moderate level of CVH, and a higher LE8 score was beneficial for reducing the risk of HUA.