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Wound complications and local recurrence do not differ when using interstitial brachytherapy versus external beam
Martina Hale1, Precious Oyem2, Haley Prough3
1Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, EC-10 Cleveland Clinic, Cleveland, OH.
Brachytherapy
|July 30, 2025
Summary
Interstitial brachytherapy (BT) and external beam radiation therapy (EBRT) show similar wound healing and oncologic outcomes for soft tissue sarcoma (STS) patients. This study found no significant difference in complications between BT and EBRT for STS treatment.
Area of Science:
- Oncology
- Surgical Oncology
- Radiation Oncology
Background:
- Interstitial brachytherapy (BT) is a viable adjuvant treatment for soft tissue sarcoma (STS).
- Limited data exists comparing wound healing profiles between BT and conventional external beam radiation therapy (EBRT).
Purpose of the Study:
- To compare wound healing complications between interstitial brachytherapy (BT) and external beam radiation therapy (EBRT) in soft tissue sarcoma (STS) patients.
- To evaluate oncologic outcomes in STS patients treated with either BT or EBRT.
Main Methods:
- A comparative retrospective cohort study of 2015-2022 STS patients receiving adjuvant BT or EBRT.
- Inclusion criteria focused on patients with planar tumor geometries suitable for either radiation modality.
- Analysis included demographic parameters, wound closure techniques, complications, and oncologic outcomes, with chi-square tests for statistical comparison.
Main Results:
- No significant difference in wound healing complications (37.5% BT vs. 30.4% EBRT, p=0.587) or reoperation rates (21.9% BT vs. 26.1% EBRT, p=0.717).
- Necrosis was the most frequent complication in both groups.
- Oncologic outcomes, including local recurrence and metastasis, were comparable between BT and EBRT cohorts.
Conclusions:
- Interstitial brachytherapy (BT) is not inferior to external beam radiation therapy (EBRT) regarding wound complication rates in selected STS patients.
- Both BT and EBRT demonstrated similar oncologic outcomes and local control for soft tissue sarcoma.
