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Activation of Integrins

Activation of Integrins

Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding...

Integrins

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Intracellular Signaling Affects Focal Adhesions

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...

Adherens Junctions

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Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types – adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
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Tooth Anatomy

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Related Experiment Video

Updated: Sep 13, 2025

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

The Link Between Integrins and Oral Diseases.

Ersha Liu¹, Liujun Zeng^1,2,3

¹Department of Oral and Maxillofacial Surgery, Centre of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

|July 30, 2025

Summary

Integrins are key cell surface proteins involved in oral diseases. This review summarizes their roles in conditions like oral cancer and periodontitis, aiding future research and treatment.

Keywords:

integrin oral squamous cell carcinoma periodontitis stomatology

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Area of Science:

Cell Biology
Oral Medicine
Biochemistry

Background:

Integrins are cell surface membrane proteins connecting the extracellular matrix to the cytoskeleton.
They are crucial in physiological and pathological processes, including tumor development and inflammation.
Integrins are actively researched in stomatology for their role in oral diseases.

Purpose of the Study:

To systematically review and synthesize current research on the roles of integrins in various oral diseases.
To provide a comprehensive summary of integrin involvement in oral biology and disease pathogenesis.
To reduce research barriers and offer a theoretical basis for preventing and treating oral diseases.

Main Methods:

A comprehensive literature search was conducted using Web of Science and PubMed databases.
The review synthesized existing research findings on integrins in oral health and disease.

Main Results:

Integrins play significant roles in oral squamous cell carcinoma, oral submucous fibrosis, and oral pemphigoid.
The review covers integrin involvement in oral mucositis, periodontal disease, and peri-implantitis.
Specific integrins are essential in the pathogenesis of these oral conditions.

Conclusions:

Integrins are vital in oral disease development and progression.
Understanding integrin function offers a foundation for novel therapeutic strategies in oral medicine.
This review consolidates knowledge to advance integrin research and clinical applications in dentistry.