Cognitive dysfunction and depression in chemotherapy patients: a cross-sectional study from Turkey

Area of Science:

• Oncology
• Neuroscience
• Psychiatry

Background:

• Cancer patients undergoing chemotherapy are susceptible to cognitive impairments and mood disturbances.
• Understanding the interplay between cognitive function and depression is crucial for patient well-being.
• Existing research indicates potential links, but further investigation in this specific population is warranted.

Purpose of the Study:

• To examine the relationship between cognitive function and depression in cancer patients receiving chemotherapy.
• To identify demographic and socioeconomic factors influencing cognitive function in this patient group.

Main Methods:

• A cross-sectional study involving 80 cancer patients prior to their second chemotherapy cycle.
• Utilized the Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog) and Beck Depression Inventory (BDI).
• Socio-demographic data were collected using a standardized form.

Main Results:

• A significant inverse correlation was found between cognitive dysfunction and depression (r = -0.525, p < 0.001).
• Moderate depressive symptoms were prevalent in 45% of the participants.
• Low income was a significant predictor of lower cognitive scores (p = 0.01).

Conclusions:

• Cancer patients on chemotherapy demonstrate significant cognitive decline and elevated depression.
• Socioeconomic status, particularly low income, negatively impacts cognitive function.
• Integration of psychosocial interventions into oncological rehabilitation is recommended.