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Necroptosis in cancer: insight from epigenetic, post-transcriptional and post-translational modifications

Jinxin Tang1,2,3,4, Yan Zhuang1,4, Yibo Zhang1,4

  • 1Department of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, 410011, China.

Journal of Hematology & Oncology
|July 30, 2025
PubMed

Insights

This review explores how epigenetic, post-transcriptional, and post-translational modifications regulate necroptosis (programmed cell death) in cancer. Understanding these mechanisms offers new therapeutic targets for cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Necroptosis is a programmed cell death pathway with anti-cancer immune potential.
  • Regulating necroptosis for cancer therapy is challenging.
  • Epigenetic, post-transcriptional, and post-translational modifications influence cancer but their role in necroptosis is unclear.

Purpose of the Study:

  • To systematically review the role of epigenetic, post-transcriptional, and post-translational modifications in regulating necroptosis in cancer.
  • To identify potential regulatory targets within these modification pathways.
  • To discuss the therapeutic implications for cancer treatment.

Main Methods:

  • Literature review focusing on molecular modifications and necroptosis in cancer.
  • Analysis of mechanisms linking epigenetic, post-transcriptional, and post-translational modifications to necroptosis.
  • Identification of key regulatory nodes and therapeutic targets.

Main Results:

  • These modifications significantly impact cancer progression and necroptosis.
  • Specific pathways and targets involved in regulating necroptosis have been identified.
  • The interplay between these modifications and necroptosis offers promising therapeutic avenues.

Conclusions:

  • Epigenetic, post-transcriptional, and post-translational modifications are critical regulators of necroptosis in cancer.
  • Targeting these modifications presents a novel strategy for cancer therapy.
  • Further research into these mechanisms will support necroptosis-based cancer treatments.
Keywords:
CancerEpigenetic modificationNecroptosisPost-transcriptional modificationPost-translational modification

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