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  1. Home
  3. Effect Of Bisphenol-a And Bisphenol-s On Functional Parameters Of Human Leukocytes.
  1. Home
  3. Effect Of Bisphenol-a And Bisphenol-s On Functional Parameters Of Human Leukocytes.

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Effect of bisphenol-A and bisphenol-S on functional parameters of human leukocytes.

Manuel Iván Girón-Pérez1,2, Guadalupe Herminia Ventura-Ramón1,2,3, Carlos Eduardo Covantes-Rosales1,2

  • 1Laboratorio de Inmunotoxicología, Secretaría de Investigación y Posgrado, Universidad Autónoma de Nayarit, Tepic, Nayarit, México.

Immunopharmacology and Immunotoxicology
|July 31, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Low-level exposure to Bisphenol A (BPA) and Bisphenol S (BPS) alters human leukocyte function. These common food packaging chemicals induce mitochondrial dysfunction and senescence, impacting immune cell health.

Keywords:
BPABPSLeukocytesapoptosisimmunotoxicityintracellular calciummitochondrial membrane potentialreactive oxygen speciessenescence

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Area of Science:

  • Immunotoxicology
  • Environmental Health
  • Biochemistry

Background:

  • Bisphenol A (BPA) and bisphenol S (BPS) are widely used in food packaging.
  • These compounds are known carcinogens and xenoestrogens.
  • Their impact on the immune system remains largely uncharacterized.

Purpose of the Study:

  • To investigate the immunotoxic effects of BPA and BPS on human peripheral blood leukocytes.
  • To assess the impact of low-concentration BPA and BPS exposure on immune cell function.

Main Methods:

  • Human peripheral blood leukocytes were exposed in vitro to BPA and BPS (0.1 ng/mL).
  • Assessed apoptosis, mitochondrial membrane potential (ΔΨm), senescence, reactive oxygen species (ROS), and intracellular Ca2+ flux using flow cytometry.

Main Results:

  • In vitro exposure to BPA or BPS did not induce leukocyte death.
  • Exposure resulted in loss of mitochondrial membrane potential (ΔΨm) and induced senescence.
  • Increased reactive oxygen species (ROS) production and intracellular Ca2+ flux were observed.

Conclusions:

  • Low concentrations of BPA and BPS, found in human blood, significantly alter leukocyte function.
  • These findings highlight potential risks to immune response from common environmental exposures.
  • Further research is needed to understand the long-term immunologic consequences.