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Updated: May 12, 2026

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

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Recent Advances in Functionalized Nanoparticles for Targeted and Controlled Inner Ear Therapy via Localized Cochlear

¹Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Journal of Audiology & Otology

|July 31, 2025

Summary

This summary is machine-generated.

Functionalized nanoparticles offer targeted delivery for sensorineural hearing loss (SNHL) treatment. These advanced systems improve drug penetration and cellular uptake, showing promise for inner ear therapies.

Keywords:

Inner ear drug delivery Nanoparticles Sensorineural hearing loss Surface functionalization

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Area of Science:

Biomedical Engineering
Nanotechnology
Otolaryngology

Background:

Sensorineural hearing loss (SNHL) presents treatment challenges due to inner ear complexity and barriers like the blood-labyrinth barrier.
Nanoparticle-based drug delivery systems are emerging as a viable strategy for targeted and sustained inner ear therapeutics.

Purpose of the Study:

To review recent advancements in nanoparticle functionalization for enhanced inner ear drug delivery.
To highlight strategies for improving cochlear targeting and therapeutic efficacy in SNHL treatment.

Main Methods:

Discussion of active targeting strategies using prestin-specific peptides for outer hair cell delivery.
Exploration of stimuli-responsive systems (thermosensitive hydrogels, light-activated nanoparticles) for controlled drug release.
Analysis of surface modifications (PEGylation, cell-penetrating peptides, cationic charges) to enhance round window membrane permeability and cellular uptake.

Main Results:

Functionalized nanoparticles demonstrate improved cochlear targeting in preclinical SNHL models.
Surface modifications enhance drug delivery across the round window membrane and increase cellular uptake.
Stimuli-responsive systems enable controlled drug release, optimizing therapeutic potential.

Conclusions:

Advanced nanoparticle functionalization strategies show significant promise for treating SNHL.
Multifunctional, biocompatible nanoparticle systems are crucial for successful clinical translation.
Targeted and stimuli-responsive drug delivery via nanoparticles offers a promising therapeutic avenue for sensorineural hearing loss.