Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

2.5K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
2.5K
Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

25.7K
Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis...
25.7K
Lipids as Anchors01:32

Lipids as Anchors

5.9K
In the plasma membrane, the lipids forming the bilayer can also act as an anchor to tether proteins to the membrane. The three main types of lipid anchors found in eukaryotes are – prenyl groups, fatty acyl groups, and glycosylphosphatidylinositol or GPI groups. Prenyl and fatty acyl groups act as anchors on the cytosolic surface of the membrane, whereas GPI anchors proteins on the extracellular side.
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains...
5.9K
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

5.3K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
5.3K
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

875
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
875
Structure of Cardiac Muscles01:13

Structure of Cardiac Muscles

14.1K
Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
14.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RNA splicing and cardiovascular disease: a guide for cardiologists.

European heart journal·2026
Same author

Force-Induced Ankle Opening Reveals Mechanical Stabilization of the Ankle of Human β-Cardiac Myosin.

ACS nano·2026
Same author

Python metabolomics uncovers a conserved postprandial metabolite and gut-brain feeding pathway.

Nature metabolism·2026
Same author

EJHF expert consensus statement on the diagnosis and management of hypertrophic cardiomyopathy.

European journal of heart failure·2026
Same author

Multi-omics Insight into Cardiac Myofibril Remodeling in Post-Prandial Burmese Pythons.

bioRxiv : the preprint server for biology·2026
Same author

Python metabolomics uncovers a conserved postprandial metabolite and gut-brain feeding pathway.

bioRxiv : the preprint server for biology·2026
Same journal

Multiomics Profiling During Autoimmune Demyelination Highlights a Complex Regulatory Role for Ataxin-1 in B Cells.

Annals of the New York Academy of Sciences·2026
Same journal

Global Trends in Light Pollution and Their Relationship With Socioeconomic Factors.

Annals of the New York Academy of Sciences·2026
Same journal

Wired for Corruption: Inter-Brain Synchrony Encodes Bribery-Related Value Information and Predicts Bribery Agreement.

Annals of the New York Academy of Sciences·2026
Same journal

LM-YOLO: A Lightweight Multi-Scale Enhanced Model for Forest Smoke Detection Using Unmanned Aerial Vehicles.

Annals of the New York Academy of Sciences·2026
Same journal

Polyrhythm Perception and Production: A Scoping Review.

Annals of the New York Academy of Sciences·2026
Same journal

DARTS-CNN-BiLSTM: Intelligent Fault Diagnosis for Computer Numerical Control Machine Tool Feed System.

Annals of the New York Academy of Sciences·2026
See all related articles

Related Experiment Video

Updated: Sep 13, 2025

Fiber Type and Subcellular-Specific Analysis of Lipid Droplet Content in Skeletal Muscle
11:50

Fiber Type and Subcellular-Specific Analysis of Lipid Droplet Content in Skeletal Muscle

Published on: June 8, 2022

4.4K

Python cardiomyocytes store lipids to buffer against hyperlipidemia.

Yuxiao Tan1,2, Angela K Peter1,2, Christopher D Ozeroff1,2

  • 1BioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, USA.

Annals of the New York Academy of Sciences
|July 31, 2025
PubMed
Summary
This summary is machine-generated.

Burmese pythons resist heart damage from high blood lipids. Their hearts use fat metabolism and storage to prevent lipotoxicity, unlike mammals.

Keywords:
cardiomyocyteshyperlipidemialipotoxicitymetabolismpython

More Related Videos

Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis
10:23

Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis

Published on: April 17, 2017

10.3K
Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
03:42

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: March 29, 2024

1.7K

Related Experiment Videos

Last Updated: Sep 13, 2025

Fiber Type and Subcellular-Specific Analysis of Lipid Droplet Content in Skeletal Muscle
11:50

Fiber Type and Subcellular-Specific Analysis of Lipid Droplet Content in Skeletal Muscle

Published on: June 8, 2022

4.4K
Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis
10:23

Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis

Published on: April 17, 2017

10.3K
Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
03:42

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: March 29, 2024

1.7K

Area of Science:

  • Comparative physiology
  • Cardiovascular adaptation
  • Lipid metabolism

Background:

  • Burmese pythons exhibit transient cardiac changes after large meals.
  • Invasive pythons in Florida consume food continuously, leading to sustained hyperlipidemia.
  • Mammalian hyperlipidemia increases risks for heart disease and metabolic syndrome.

Purpose of the Study:

  • To investigate the cardiac resistance of Burmese pythons to chronic hyperlipidemia.
  • To determine if python hearts are protected from lipotoxicity despite sustained high lipid levels.

Main Methods:

  • A chronic frequent feeding regimen was implemented for Burmese pythons over 8 weeks.
  • Sustained hyperlipidemia was induced in the python circulatory system.
  • Cardiac responses to hyperlipidemia were analyzed, focusing on lipid metabolism and stress pathways.

Main Results:

  • Python hearts demonstrated dynamic oxidative lipid metabolism.
  • A heightened capacity for fat storage was observed in python cardiac tissue.
  • Dampened stress kinase responses indicated protection against lipid-induced damage.
  • The python circulatory system exhibited sustained hyperlipidemia for 8 weeks.

Conclusions:

  • Burmese python hearts are protected from the adverse effects of hyperlipidemia.
  • Dynamic lipid metabolism, fat storage, and reduced stress responses contribute to cardiac resilience.
  • These findings suggest evolved mechanisms in pythons to mitigate cardiac risks associated with high lipid levels.