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Effective Transcriptional Induction of the CARMN/miR-143/145 Complex Locus in Smooth Muscle Cells Using CRISPR

Francesca Vacante1,2, Sandra Sanchez-Esteban1, Themistoklis Tsarouchas3,2

  • 1Queens Medical Research Institute, BHF Centre for Cardiovascular Sciences, University of Edinburgh, Scotland (F.V., S.S.-E., J.R., M.B., A.B., A.H.B.).

Arteriosclerosis, Thrombosis, and Vascular Biology
|July 31, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
RNA, long noncodingcardiovascular diseasesmicroRNAsmuscle, smooth, vasculartranscriptional activation

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Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...

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