Related Experiment Video
Updated: Sep 13, 2025
06:18
A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
Published on: March 3, 2023
1.5K
Continuous, In Situ Targeted, Ultrahigh-Concentration Antibiotics for Infections from Cardiac Implantable Electronic
Yi-Pan Li1, Yu-Ning Hu2, Ju-Yi Chen3
1Division of Cardiology, Department of Internal Medicine, Kaohsiung Show Chwan Memorial Hospital, Kaohsiung.
Acta Cardiologica Sinica
|July 31, 2025
Summary
Complete removal of cardiac implantable electronic devices (CIEDs) is standard for infection, but carries risks. Continuous, in situ targeted, ultrahigh-concentration antibiotics (CITAs) show promise as a less invasive alternative for localized CIED infections.
Area of Science:
- Cardiology
- Infectious Diseases
- Medical Devices
Background:
- Cardiac implantable electronic device (CIED) infections necessitate device removal and antibiotics per current consensus.
- Lead extraction, while effective, poses significant risks of complications and mortality.
- Alternative treatments are needed for high-risk patients with localized CIED infections.
Purpose of the Study:
- To describe the details and evaluate the effectiveness of continuous, in situ targeted, ultrahigh-concentration antibiotics (CITAs) for localized CIED infections.
- To assess CITA as a potential alternative to lead extraction in specific patient populations.
Main Methods:
- Case series describing the application of CITA treatment.
- Review of treatment outcomes for four patients with localized CIED infections.
Main Results:
- Three out of four patients successfully avoided CIED lead extraction using CITA therapy.
- The CITA approach demonstrated a high success rate in these cases without major complications.
Conclusions:
- Continuous, in situ targeted, ultrahigh-concentration antibiotics (CITAs) represent a promising conservative treatment for localized CIED infections.
- CITAs may offer a viable alternative to lead extraction, particularly in high-risk patients.
- Further prospective studies are required to validate CITA effectiveness and potentially update clinical guidelines.
Keywords:
Cardiac implantable electronic devicesContinuousIn situ-targetedInfectionUltrahigh concentration of antibioticsMore Related Videos
07:48High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue
Published on: September 30, 2022
1.4K
16:40A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation
Published on: February 28, 2012
26.3K
Related Concept Videos
01:18Endocarditis III: Medical Management
19
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
19
01:29Endocarditis IV: Nursing Management
31
Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
31
01:25Endocarditis I: Introduction
26
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
26
01:26Cardiac Catheterization IV: Nursing Management
193
Nursing responsibilities before cardiac catheterization include:Assess for allergies and establish baseline health status.Before cardiac catheterization, assess the patient for allergies to contrast dye. Perform a comprehensive baseline assessment, including vital signs, heart and breath sounds, and a neurovascular assessment of the extremities, noting distal pulses, skin color, and temperature. Instruct the patient to fast for 8-12 hours before the procedure. Evaluate baseline laboratory...
193
01:30Bacterial Signaling
34.2K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
34.2K
01:29Cardiomyopathy V: Interprofessional Care
34
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
34