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Papillary Dermis

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...

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Updated: Jul 6, 2026

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Published on: May 28, 2021

A dermis-on-a-chip model for compound screening.

Dhana Abdo¹, Yimu Zhao², Sargol Okhovatian^3,4

¹Department of Chemical Engineering and Applied Chemistry, University of Toronto, 27 King's College Circle, Toronto, ON, M5S 1A1, Canada.

Materials Today. Bio

|July 31, 2025

Summary

This summary is machine-generated.

A novel dermis-on-a-chip model accurately replicates dermal fibrosis (scarring) in 3D microtissues. This platform effectively screens anti-fibrotic compounds, showing promise for improved wound healing therapies.

Keywords:

Dermis Fibroblast Fibrosis Organ-on-a-chip Peptide

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Last Updated: Jul 6, 2026

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Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip

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Published on: February 17, 2023

Area of Science:

Biomedical Engineering
Tissue Engineering
Dermatology

Background:

Dermal fibrosis impedes wound healing due to excessive myofibroblast activation and extracellular matrix deposition.
Existing in vitro models like monolayer cultures and human skin equivalents (HSEs) lack physiological relevance and scalability for drug screening.
Developing advanced models is crucial for understanding fibrosis and identifying effective anti-fibrotic therapies.

Purpose of the Study:

To develop and validate a dermis-on-a-chip platform for studying dermal fibrosis.
To assess the platform's utility in screening anti-fibrotic compounds.
To investigate the effects of a regenerative peptide (Q-peptide) on fibrotic responses.

Main Methods:

Fabrication of a 3D dermis-on-a-chip platform housing dermal microtissues.
Induction of fibrotic hallmarks in microtissues using transforming growth factor beta (TGFβ).
Treatment of fibrotic microtissues with Q-peptide and assessment of fibrotic markers.

Main Results:

TGFβ treatment induced key fibrotic features: impaired integrity, increased tensile forces, altered cell morphology, and a pro-fibrotic cytokine profile.
Q-peptide selectively mitigated TGFβ-induced fibrotic changes.
Q-peptide reduced tensile forces, suppressed smooth muscle actin (SMA) expression, and modulated cytokine profiles.

Conclusions:

The dermis-on-a-chip platform provides a physiologically relevant model for studying dermal fibrosis.
This model is effective for screening anti-fibrotic compounds and understanding their mechanisms.
Findings highlight the potential of Q-peptide in modulating fibrotic processes for enhanced wound repair.