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Related Experiment Videos

Reserpine in propranolol-resistant thyroid storm.

E Anaissie, J F Tohmé

    Archives of Internal Medicine
    |December 1, 1985
    PubMed
    Summary
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    Beta-adrenergic blockers are standard for hyperthyroidism. However, one patient with thyroid storm unresponsive to propranolol responded well to reserpine, suggesting its use in resistant cases.

    Area of Science:

    • Endocrinology
    • Pharmacology

    Background:

    • Beta-adrenergic blockers are first-line treatments for the hyperadrenergic state in hyperthyroidism.
    • Thyroid storm is a severe manifestation requiring prompt management.

    Observation:

    • A patient in thyroid storm and coma presented with resistance to high doses of propranolol hydrochloride (oral and IV).
    • The patient showed a rapid positive response to intramuscular reserpine administration.

    Findings:

    • Reserpine demonstrated efficacy in a case of propranolol-resistant hyperthyroidism.
    • Intramuscular reserpine was effective where propranolol failed.

    Implications:

    • Reserpine should be considered as a potential therapeutic option for propranolol-resistant hyperthyroidism.

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  • Reserpine may be a life-saving alternative for hyperthyroid patients unresponsive to or contraindicated for propranolol.