Related Experiment Video
Updated: Sep 13, 2025
05:16
Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
3.5K
A Systematic Evidence-Based Review Regarding miRNA Polymorphisms in Recurrent Implantation Failure
Bogdan Doroftei1,2,3, Ovidiu-Dumitru Ilie1, Ana-Maria Dabuleanu1,2,3
1Department of Mother and Child, Faculty of Medicine University of Medicine and Pharmacy "Grigore T. Popa" Iasi Romania.
Reproductive Medicine and Biology
|July 31, 2025
Summary
Specific single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) are linked to recurrent implantation failure (RIF). Certain miRNA SNPs and haplotypes increase RIF susceptibility, while others offer protection.
Area of Science:
- Reproductive Medicine
- Genetics
- Molecular Biology
Background:
- Recurrent implantation failure (RIF) is a complex reproductive challenge.
- The role of genetic variations, specifically single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs), in RIF is under investigation.
Purpose of the Study:
- To systematically review and evaluate the association between specific miRNA SNPs and RIF.
- To identify miRNA SNPs and haplotypes that confer susceptibility or protection against RIF.
Main Methods:
- A comprehensive literature search was performed across major scientific databases (PubMed-MEDLINE, Web of Science, Scopus, EMBASE).
- Studies were assessed for quality using the Newcastle-Ottawa Scale (NOS).
Main Results:
- Several miRNA SNPs and haplotype combinations were identified as risk factors for RIF, including specific genotypes of miR-196a, miR-449b, and miR-34a.
- Protective combinations of miRNA SNPs, such as those involving miR-1302-3 and miR-938, were also identified.
- Specific miRNA SNPs were associated with altered coagulation parameters, hormone levels (FSH, TSH), and kidney function markers (creatinine, BUN).
Conclusions:
- Specific miRNA SNPs and their haplotype combinations are significantly associated with RIF susceptibility or protection.
- These findings contribute to understanding the genetic underpinnings of RIF and may inform future diagnostic or therapeutic strategies.
