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Updated: Sep 13, 2025

Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents
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Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents

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Debating the link between atrial fibrillation and psychiatric diseases through Ca2+/cAMP signaling

Leandro Bueno Bergantin1

  • 1Department of Pharmacology, Universidade Federal de São Paulo, São Paulo 04039-032, Brazil. leanbio39@yahoo.com.br.

World Journal of Psychiatry
|July 31, 2025
PubMed

Insights

Atrial fibrillation (AF), a common heart rhythm disorder, is linked to psychiatric conditions. This review explores the connection through the lens of calcium/cyclic AMP signaling pathways.

Area of Science:

  • Cardiology
  • Neuroscience
  • Molecular Biology

Background:

  • Atrial fibrillation (AF) is a prevalent tachyarrhythmia with numerous established risk factors.
  • Existing research suggests a potential association between AF and psychiatric diseases, warranting further investigation.
  • Understanding these links can improve patient care and reduce healthcare burdens.

Purpose of the Study:

  • To explore the relationship between atrial fibrillation and psychiatric diseases.
  • To examine the role of Ca2+/cAMP signaling in the context of AF and psychiatric comorbidities.
  • To provide a comprehensive overview of current research and potential mechanisms.

Main Methods:

  • Literature review of studies investigating AF, psychiatric diseases, and Ca2+/cAMP signaling.
  • Analysis of proposed pathophysiological mechanisms linking these conditions.
  • Synthesis of findings from clinical and experimental research.

Main Results:

  • Several risk factors for AF are identified, including inflammation, diabetes, hypertension, and obesity.
  • Emerging evidence points to a significant link between AF and various psychiatric disorders.
  • Ca2+/cAMP signaling pathways are implicated as potential mediators in the AF-psychiatric disease relationship.

Conclusions:

  • The interplay between AF and psychiatric diseases is complex and multifactorial.
  • Ca2+/cAMP signaling represents a promising area for understanding the underlying mechanisms.
  • Further research is needed to elucidate these pathways and develop targeted therapeutic strategies.

Keywords:
Atrial fibrillationCa2+/cAMP signalingInflammatory diseasesNeurotransmittersPsychiatric diseases

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