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Repetitive Transcranial Magnetic Stimulation to the Unilateral Hemisphere of Rat Brain
Published on: October 22, 2016
Effects of repetitive transcranial magnetic stimulation on electroencephalogram and memory function in patients with
1Rehabilitation Medicine Center, The First Hospital of Shanxi Medical University, Taiyuan 030000, Shanxi Province, China. fuhaixia1993@163.com.
Background:
Mild cognitive impairment (MCI) is a high-risk precursor to Alzheimer's disease characterized by declining memory or other progressive cognitive functions without compromising daily living abilities.
Aim:
To investigate the efficacy of repetitive transcranial magnetic stimulation (rTMS) in patients with MCI.
Methods:
This retrospective analysis involved 180 patients with MCI who were admitted to The First Hospital of Shanxi Medical University from January 2021 to June 2023. Participants were allocated into the research (n = 98, receiving rTMS) and control groups (n = 82, receiving sham stimulation). Memory tests, cognitive function assessments, event-related potential-P300 tests, and electroencephalogram (EEG) examinations were conducted pre-treatment and post-treatment. Further, memory quotient (MQ), cognitive function scores, and EEG grading results were compared, along with adverse reaction incidences.
Results:
Pre-treatment MQ scores, long-term and short-term memory, as well as immediate memory scores, demonstrated no notable differences between the groups. Post-treatment, the research group exhibited significant increases in MQ scores, long-term memory, and short-term memory compared to baseline (P < 0.05), with these improvements being statistically superior to those in the control group. However, immediate memory scores exhibited no significant change (P > 0.05). Further, the research group demonstrated statistically better post-treatment scores on the Revised Wechsler Memory Scale than the control group. Furthermore, post-treatment P300 latency and amplitude improved significantly in the research group, surpassing the control group. EEG grading in the research group improved, and the incidence of adverse reactions was significantly lower than in the control group.
Conclusion:
Patients with MCI receiving rTMS therapy demonstrated improved memory and cognitive functions and EEG grading and exhibited high safety with fewer adverse reactions.
Insights
Repetitive transcranial magnetic stimulation (rTMS) significantly improved memory and cognitive functions in mild cognitive impairment (MCI) patients. This safe therapy also enhanced EEG grading with fewer adverse effects compared to sham treatment.
Area of Science:
- Neurology
- Neuroscience
- Medical Technology
Background:
- Mild cognitive impairment (MCI) is a critical precursor to Alzheimer's disease.
- MCI is characterized by cognitive decline without significant impact on daily living.
- Early intervention is crucial for managing MCI progression.
Purpose of the Study:
- To evaluate the therapeutic efficacy of repetitive transcranial magnetic stimulation (rTMS) in patients diagnosed with MCI.
- To assess the impact of rTMS on memory, cognitive function, and electrophysiological markers in MCI.
- To compare the safety profile of rTMS versus sham stimulation in MCI patients.
Main Methods:
- Retrospective analysis of 180 MCI patients from January 2021 to June 2023.
- Two groups: rTMS treatment (n=98) and sham stimulation (n=82).
- Evaluated memory (MQ, immediate, short-term, long-term), cognitive function (Revised Wechsler Memory Scale), event-related potential-P300, and EEG grading pre- and post-treatment.
Main Results:
- rTMS significantly improved memory quotient, long-term, and short-term memory recall post-treatment (P < 0.05).
- The rTMS group showed superior performance on the Revised Wechsler Memory Scale and improved P300 latency and amplitude.
- rTMS led to better EEG grading and a significantly lower incidence of adverse reactions compared to the control group.
Conclusions:
- Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for enhancing memory and cognitive functions in MCI patients.
- rTMS therapy demonstrates significant improvements in electrophysiological markers (EEG, P300) and cognitive assessments.
- rTMS exhibits a favorable safety profile with minimal adverse reactions, making it a viable therapeutic option for MCI.
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