Related Experiment Video
Updated: Sep 13, 2025

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
Published on: April 12, 2015
Regulation and intervention of stem cell differentiation by long non-coding RNAs: Mechanisms and therapeutic
Ye-Hua Li1, Yi-Ning Yao1, Shen-Ao Zhou2,3
1College of Life Science, Northwest Normal University, Lanzhou 730070, Gansu Province, China.
Abstract:
Long non-coding RNAs (lncRNAs) play pivotal roles in the regulation of gene expression, particularly in maintaining pluripotency and directing stem cell. By orchestrating stem cell fate decisions and lineage commitment through epigenetic, transcriptional, and post-transcriptional mechanisms, lncRNAs have emerged as key modulators in developmental biology. Their therapeutic potential has garnered increasing interest, especially in the contexts of regenerative medicine, disease modeling, targeted delivery systems, and precision therapeutics. This review presents a comprehensive overview of the mechanisms by which lncRNAs govern stem cell differentiation and examines emerging lncRNA-based therapeutic strategies, emphasizing major challenges and prospective research directions in this rapidly advancing field.
More Related Videos
11:37Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting
Published on: June 18, 2018
06:55Transient Treatment of Human Pluripotent Stem Cells with DMSO to Promote Differentiation
Published on: July 17, 2019
Related Concept Videos
lncRNA - Long Non-coding RNAs
Stem Cell Culture
Regulation of Hematopoietic Stem Cells
iPS Cell Differentiation
Maintenance of the ES Cell State
Regulation of Expression at Multiple Steps