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Exploring the synergistic effects of Life's Essential 8, insulin resistance, and CRP on cardiometabolic

Jiang Liu1, Chuang Yang2, Wenke Cheng2

  • 1Department of Cardiology, Yingtan People's Hospital, Yingtan, Jiangxi Province, China.

Frontiers in Nutrition
|July 31, 2025
PubMed

Insights

Maintaining high cardiovascular health, measured by Life's Essential 8 (LE8), significantly lowers the risk of developing cardiometabolic multimorbidity (CMM). This protective effect is partly due to reduced insulin resistance and inflammation.

Area of Science:

  • Cardiology
  • Public Health
  • Metabolic Disease Research

Background:

  • Cardiometabolic multimorbidity (CMM) is the co-occurrence of diseases like coronary artery disease, stroke, and type 2 diabetes.
  • Life's Essential 8 (LE8) is a metric for cardiovascular health (CVH) that includes behavioral and metabolic factors.
  • The relationship between LE8 and CMM risk has not been previously explored.

Purpose of the Study:

  • To investigate the independent and combined effects of LE8, insulin resistance (IR), and C-reactive protein (CRP) on CMM risk.
  • To determine the extent to which IR and CRP mediate the association between LE8 and CMM.

Main Methods:

  • A prospective cohort study of 304,568 UK Biobank participants without baseline CMM.
  • Cox proportional hazards models and restricted cubic splines assessed LE8 and CMM risk.
  • Mediation analyses identified the roles of triglyceride-glucose index (TyG) and CRP.

Main Results:

  • Higher LE8 scores were linked to a significantly reduced risk of CMM (HR per 10-point increase: 0.65).
  • Increased LE8 scores delayed CMM onset by up to 47.3 months.
  • TyG and CRP mediated 18.8% and 2.9% of LE8's protective effect, respectively.

Conclusions:

  • High LE8 scores are associated with a lower risk of developing CMM.
  • Reductions in IR and inflammation partially mediate this protective effect.
  • Promoting CVH and addressing metabolic/inflammatory factors may prevent CMM.
Abstract

Keywords:
Life’s Essential 8cardiometabolic multimorbiditytriglyceride glucosetriglyceride glucose-body mass indextriglyceride glucose-waist circumferencetriglyceride glucose-waist height ratio

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