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Related Concept Videos

Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
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Secondary Lymphoid Organs

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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
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Primary Lymphoid Organs01:16

Primary Lymphoid Organs

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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
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Detailed Structure and Function of Lymph Nodes01:23

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Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
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Development of the Lymphatic System01:15

Development of the Lymphatic System

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The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
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Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

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Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
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Updated: Sep 13, 2025

Isolation of Murine Lymph Node Stromal Cells
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Isolation of Murine Lymph Node Stromal Cells

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Lymphoid stroma in all its states.

Nicolas Barbier1,2, Valentin Isen1, Karin Tarte1,2

  • 1UMR 1236, Univ Rennes, INSERM, Établissement Français du Sang, Équipe Labellisée Ligue contre le cancer, Rennes, France.

Frontiers in Immunology
|July 31, 2025
PubMed
Summary
This summary is machine-generated.

Lymphoid stromal cells (LSCs) are crucial in immune responses and tissue organization. Understanding LSC diversity and plasticity offers potential for new cancer and autoimmune disease therapies.

Keywords:
lymph nodelymphoid stromal cellslymphomatertiary lymphoid structuretumor draining lymph node

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Area of Science:

  • Immunology
  • Cell Biology
  • Pathology

Background:

  • Stromal cells are ubiquitous in tissues; lymphoid stromal cells (LSCs) reside in lymphoid organs.
  • LSC heterogeneity is well-defined in mice and increasingly studied in humans.
  • LSCs form niches and orchestrate adaptive immunity.

Purpose of the Study:

  • To review the diversity and plasticity of LSCs and LSC-like cells.
  • To explore LSC functions in pathological settings, focusing on cancer and autoimmune diseases.
  • To emphasize the therapeutic potential of targeting LSCs.

Main Methods:

  • Cell-fate mapping
  • High-resolution imaging
  • Single-cell RNA sequencing (scRNA-seq)

Main Results:

  • LSCs exhibit significant heterogeneity and plasticity.
  • LSCs play diverse roles in solid tumors, autoimmune diseases, and lymphomas.
  • LSC-like cells are implicated in various pathological conditions.

Conclusions:

  • Further understanding of LSCs is vital for developing novel therapeutic strategies.
  • Targeting LSCs may offer new avenues for treating cancer and autoimmune diseases.
  • LSCs are key players in both homeostasis and disease pathogenesis.