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Updated: Sep 13, 2025

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
Published on: July 31, 2019
Intestinal microbiota characteristics and dietary fiber intervention in patients undergoing endoscopic mucosa
Wen-Cui Niu1, Shao-Hua Wang2, Ye Zhao3
1Department of Nutrition, Beijing Hospital of Integrated Traditional Chinese and Western Medicine, Beijing 100039, China.
Background:
Endoscopic mucosa resection (EMR) is an important minimally invasive surgical method for treating early digestive tract tumors. In recent years, the crucial role of intestinal microbiota in disease occurrence and development has attracted increasing attention. However, the changes in intestinal microbiota after EMR and the effect of dietary fiber intervention on microbiota recovery remain insufficiently elucidated.
Aim:
To investigate the effects of dietary fiber intervention on intestinal microbiota recovery in patients undergoing EMR and evaluate its potential to improve postoperative outcomes and intestinal microecological balance.
Methods:
This retrospective study analyzed intestinal microbiota sequencing and dietary fiber intervention in patients with EMR. Patients who underwent EMR surgery between 2020 and 2023 were selected and divided into a routine follow-up group and a dietary fiber intervention group. High-throughput 16S rRNA gene sequencing was performed to detect changes in patient intestinal microbiota, and microbiota diversity, structure, and function in different intervention groups were compared and analyzed.
Results:
A total of 86 patients with EMR were included in the study. Results showed that: (1) Intestinal microbiota diversity significantly decreased after EMR surgery, with notable changes in the proportion of Gram-negative bacilli and anaerobic bacteria; (2) The microbiota recovery rate in the dietary fiber intervention group was significantly higher than that in the control group, with a significantly higher microbiota diversity index (P < 0.05); and (3) The abundance of lactobacilli and bifidobacteria in the intervention group increased substantially, and intestinal barrier-related functional gene expression was upregulated.
Conclusion:
Dietary fiber intervention can effectively promote intestinal microbiota recovery in patients with EMR, improve intestinal microecological balance, and provide a new intervention strategy for clinical post-EMR patient rehabilitation.
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