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Related Concept Videos

Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

146
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
146
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents01:20

Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents

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The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
599
Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors01:13

Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors

525
Peptic ulcers, often induced by H. pylori infections or NSAID usage, arise from disruptions in the delicate balance of gastric acid production. Peptic ulcers stem from heightened gastric acid levels due to H. pylori infections or NSAID use. The protective mucus layer diminishes in the presence of these factors, allowing gastric acid to erode the stomach lining and form ulcers.
Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
525
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents01:24

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

694
In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
694
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

292
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
292
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors01:24

Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors

580
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI)  tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
580

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Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release
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Novel Curcumin Floating Tablets for Spatial Delivery in Peptic Ulcer.

Chitra Gupta1, Girdhar Kumar Sahu1, Ashish Kumar Parashar1

  • 1Department of Pharmaceutics, Lloyd Institute of Management and Technology, Greater Noida, 201306, India.

Biomed Research International
|July 31, 2025
PubMed
Summary
This summary is machine-generated.

This study developed novel floating tablets to improve curcumin delivery for peptic ulcer treatment. The gastroretentive system enhances curcumin

Keywords:
Helicobacter pyloricurcumincyclodextran complexfloating tabletgastroretentivepeptic ulcerssolvent evaporation method

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Natural Product Therapeutics

Background:

  • Peptic ulcers are commonly treated with drugs that have side effects.
  • Curcumin shows therapeutic potential but suffers from poor solubility and instability.
  • Novel drug delivery systems are needed to enhance curcumin's efficacy for peptic ulcer treatment.

Purpose of the Study:

  • To develop an innovative drug delivery system to overcome curcumin's bioavailability limitations.
  • To formulate effervescent, gastroretentive tablets for sustained gastric retention and localized curcumin release.

Main Methods:

  • Curcumin solubility was enhanced through complexation with methyl-β-cyclodextrin.
  • Effervescent, gastroretentive tablets were formulated using hypromellose and gas-generating agents.
  • Tablet properties, gastroretention, and in vitro drug release were evaluated.

Main Results:

  • Tablets met pharmaceutical standards for hardness, friability, and drug content.
  • Tablets achieved rapid flotation (within 20s) and sustained buoyancy for ~16 hours.
  • In vitro studies showed sustained drug release (73.92% in 9h) via quasi-Fickian diffusion.

Conclusions:

  • A novel floating tablet system effectively enhances curcumin delivery for peptic ulcer management.
  • The system utilizes cyclodextrin complexation and gastroretentive properties for improved bioavailability.
  • This approach holds promise for addressing unmet needs in peptic ulcer treatment.