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Updated: Sep 13, 2025

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
Published on: December 1, 2013
HOXC6-TIMELESS axis: Unveiling novel therapeutic strategies in bladder cancer
Meng-Meng Shi1, Ming-Yue Guan1, Shi Li1
1School of Life and Health Sciences, Institute of Biomedical Research, National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, Hubei Province, China.
Abstract:
Bladder cancer (BLCA) is a highly invasive malignancy with limited targeted therapies. Lu et al reveal the oncogenic role of HOXC6 in BLCA by showing its elevated mRNA and protein levels in cancerous tissues. Silencing HOXC6 significantly inhibits BLCA cell proliferation, migration and invasion, induces apoptosis and arrests the cell cycle at G0/G1. In addition, HOXC6 also regulates pathways related to chemical carcinogenesis and reactive oxygen species, with a strong association with the target gene TIMELESS, supported by binding signals in its promoter region. Here, we discuss the role of HOXC6 as a potential biomarker and therapeutic target, contributing to a deeper understanding of the HOXC6-TIMELESS axis and its implications for advancing BLCA research and therapy.
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