Multi-phase Training in Virus-Like Particle Synthesis to Foster Science Self-efficacy in Students With Minimal...

Area of Science:

• Molecular Biology
• Biotechnology
• Nanoparticle Synthesis

Background:

• Science self-efficacy influences success and persistence in STEM fields.
• Molecular biology techniques, such as virus-like particle (VLP) synthesis, can be challenging for novice researchers.
• Bacteriophage-derived VLPs offer potential in biomedical applications like vaccine and drug delivery.

Purpose of the Study:

• To provide research laboratories with effective methods for teaching and mentoring students in VLP synthesis and characterization.
• To address the challenges faced by new researchers with limited experience in molecular biology.
• To implement a training protocol designed to increase science self-efficacy.

Main Methods:

• A multi-phase training protocol was developed and implemented for new students.
• The protocol focused on VLP synthesis, purification, and characterization.
• The training model was optimized for high school and undergraduate students, incorporating peer-to-peer training.

Main Results:

• The multi-phase training methodology successfully increased students' confidence in performing specific scientific tasks.
• The protocol likely enhanced students' persistence in STEM fields.
• Peer-to-peer training was identified as a successful component of the methodology.

Conclusions:

• The developed multi-phase training protocol effectively enhances science self-efficacy in novice molecular biology researchers.
• This approach can improve student confidence and persistence in STEM, particularly in VLP synthesis.
• The protocol is a valuable resource for laboratories mentoring new students in complex scientific techniques.