Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

281
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
281
Seizures: Classification01:13

Seizures: Classification

596
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
596

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spatial-temporal epidemiological characteristics of influenza and its correlation with meteorological factors in Gansu province based on 24 solar terms.

BMC public health·2026
Same author

Manual Massage Therapy for Neuropathic Pain: Clinical Evidence and Mechanistic Insights.

Pain research & management·2026
Same author

Micro-sized aerobic heterotrophic ammonium assimilation granules and microbial community assembly under varying hydraulic shear force.

Bioresource technology·2026
Same author

MicroRNA-181a-5p promotes papillary thyroid carcinoma progress via the PTEN/AKT pathway.

Molecular biotechnology·2026
Same author

Protective Effects of Recombinant <i>Lactobacillus paracasei</i> Expressing Porcine β-Defensin 2 Against DSS-Induced Colitis in a Murine Model.

Animals : an open access journal from MDPI·2026
Same author

Application of ultrasound-guided percutaneous catheter drainage in the treatment of tuberculous psoas abscesses.

Frontiers in medicine·2026

Related Experiment Video

Updated: Sep 13, 2025

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
09:07

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

Published on: August 15, 2017

12.2K

A Novel Composite Method of Post-stroke Epilepsy Induction.

Yiting Guo1, Raymond Tak Fai Cheung1,2

  • 1Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong.

Bio-Protocol
|July 31, 2025
PubMed
Summary

Researchers developed a new rat model for post-stroke epilepsy (PSE) by combining stroke and epilepsy induction methods. This model shows promise for studying PSE pathogenesis and treatments.

Keywords:
EpilepsyMossy fiber sproutingOpen fieldPhotothrombosisPost-stroke epilepsy

More Related Videos

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
06:45

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

Published on: January 19, 2019

9.1K
Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury
07:07

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury

Published on: February 10, 2020

10.7K

Related Experiment Videos

Last Updated: Sep 13, 2025

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
09:07

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

Published on: August 15, 2017

12.2K
Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
06:45

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

Published on: January 19, 2019

9.1K
Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury
07:07

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury

Published on: February 10, 2020

10.7K

Area of Science:

  • Neuroscience
  • Epileptology
  • Stroke Research

Background:

  • Global stroke burden is rising, with post-stroke epilepsy (PSE) a frequent complication.
  • The precise mechanisms driving PSE remain poorly understood.
  • Existing animal models for PSE have limited success rates in inducing epilepsy.

Purpose of the Study:

  • To establish a novel and effective rat model for investigating post-stroke epilepsy (PSE).
  • To assess the utility of this new model for studying PSE-related behavioral and pathological changes.

Main Methods:

  • A composite model was created by inducing photothrombotic stroke followed by lithium-pilocarpine-induced status epilepticus in rats.
  • Key outcome measures included successful status epilepticus induction and 3-day mortality rates.
  • Preliminary assessments involved open-field tests for behavior and Zinc transporter 3 staining for mossy fiber sprouting (MFS).

Main Results:

  • The novel model achieved a high success rate (94%) for status epilepticus induction.
  • The 3-day mortality rate following status epilepticus was 25%.
  • Preliminary data indicated reduced anxiety and mossy fiber sprouting in the hippocampus of PSE rats.

Conclusions:

  • This combined photothrombotic stroke and lithium-pilocarpine model offers a robust platform for PSE research.
  • The model facilitates future investigations into the underlying mechanisms and therapeutic strategies for post-stroke epilepsy.