Related Experiment Video
Updated: Sep 13, 2025
Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
Published on: December 2, 2022
Corneally displaced conjunctival Melanoma: Rare presentations of recurrent melanoma
Eric Boya Lee1, Ahmad Al-Moujahed2, Michael D Yu2
1Wills Eye Hospital, 840 Walnut Street, Philadelphia, PA, 19107, USA.
Purpose:
To describe long term follow-up of two cases of corneally displaced conjunctival melanoma with multiple recurrences.
Observations:
Case 1 is a 49-year-old male with recurrent conjunctival melanoma and primary acquired melanosis treated over 13 years, who eventually presented with an elevated amelanotic corneal mass. Case 2 is a 61-year-old female with a similar history of recurrent conjunctival melanoma and primary acquired melanosis treated over 21 years, who presented with a subepithelial corneal opacity. Both patients were treated with a combination of topical chemotherapy, wide excision, map biopsy, cryotherapy, and local and systemic workup showing no evidence of metastasis.
Conclusions And Importance:
Conjunctival melanoma has a high risk of recurrence and can present as amelanotic corneally displaced conjunctival melanoma, warranting thorough workup to detect potential subclinical spread of the disease.
More Related Videos
06:15Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
06:46Ortho- and Ectopic Zebrafish Xeno-Engraftment of Ocular Melanoma to Recapitulate Primary Tumor and Experimental Metastasis Development
Published on: September 4, 2021
Related Concept Videos
01:30Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
02:30Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
01:21Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...