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Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes
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Therapeutic peptides and their delivery using lipid-based nanoparticles.

Jui-Hung Yen1, Chun-Chun Chang2,3, Tien-Yuan Wu4

  • 1Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien, Taiwan.

Tzu Chi Medical Journal
|July 31, 2025
PubMed
Summary

Therapeutic peptides offer targeted drug delivery but face stability challenges. Lipid-based nanoparticles show promise for protecting peptides and improving their delivery, including oral administration.

Keywords:
Computer-aided peptide designDrug deliveryLipid-based nanoparticlesLiposomesPeptide therapeutics

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Area of Science:

  • Pharmacology and Drug Discovery
  • Nanotechnology in Medicine
  • Biomaterials Science

Background:

  • Therapeutic peptides are valuable for drug discovery due to specificity and efficacy.
  • Over 100 peptide-based drugs are approved, with many more in clinical trials.
  • Peptides face limitations including poor *in vivo* stability, short half-life, and low oral bioavailability.

Purpose of the Study:

  • To review the current status of therapeutic peptide development.
  • To explore the use of lipid-based nanoparticles as drug carriers for peptides.
  • To discuss recent advances in oral delivery of therapeutic peptides using lipid nanoparticles.

Main Methods:

  • Comprehensive literature review of therapeutic peptides and lipid-based nanoparticles.
  • Analysis of examples showcasing peptide-nanoparticle formulations.
  • Discussion of strategies for enhancing peptide stability and delivery.

Main Results:

  • Lipid-based nanoparticles offer biocompatibility and biodegradability for effective peptide delivery.
  • These nanoparticles can protect peptides from enzymatic degradation and improve *in vivo* stability.
  • Emerging research focuses on utilizing lipid nanoparticles for oral peptide delivery.

Conclusions:

  • Lipid-based nanoparticles represent a promising strategy to overcome the limitations of therapeutic peptides.
  • Further development of these nanocarriers can enhance peptide efficacy and expand therapeutic applications.
  • Nanoparticle-mediated delivery holds potential for improving oral bioavailability of peptide drugs.