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Therapeutic peptides and their delivery using lipid-based nanoparticles.
Jui-Hung Yen1, Chun-Chun Chang2,3, Tien-Yuan Wu4
1Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien, Taiwan.
Tzu Chi Medical Journal
|July 31, 2025
Summary
Therapeutic peptides offer targeted drug delivery but face stability challenges. Lipid-based nanoparticles show promise for protecting peptides and improving their delivery, including oral administration.
Area of Science:
- Pharmacology and Drug Discovery
- Nanotechnology in Medicine
- Biomaterials Science
Background:
- Therapeutic peptides are valuable for drug discovery due to specificity and efficacy.
- Over 100 peptide-based drugs are approved, with many more in clinical trials.
- Peptides face limitations including poor *in vivo* stability, short half-life, and low oral bioavailability.
Purpose of the Study:
- To review the current status of therapeutic peptide development.
- To explore the use of lipid-based nanoparticles as drug carriers for peptides.
- To discuss recent advances in oral delivery of therapeutic peptides using lipid nanoparticles.
Main Methods:
- Comprehensive literature review of therapeutic peptides and lipid-based nanoparticles.
- Analysis of examples showcasing peptide-nanoparticle formulations.
- Discussion of strategies for enhancing peptide stability and delivery.
Main Results:
- Lipid-based nanoparticles offer biocompatibility and biodegradability for effective peptide delivery.
- These nanoparticles can protect peptides from enzymatic degradation and improve *in vivo* stability.
- Emerging research focuses on utilizing lipid nanoparticles for oral peptide delivery.
Conclusions:
- Lipid-based nanoparticles represent a promising strategy to overcome the limitations of therapeutic peptides.
- Further development of these nanocarriers can enhance peptide efficacy and expand therapeutic applications.
- Nanoparticle-mediated delivery holds potential for improving oral bioavailability of peptide drugs.
Keywords:
Computer-aided peptide designDrug deliveryLipid-based nanoparticlesLiposomesPeptide therapeuticsMore Related Videos
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