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Updated: Sep 13, 2025

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
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Correlation Between External and Internal Skin Aging Markers by Skin Depth.

Hye-Yeon Yang1, Sung-Ha Park1, Ji-Eun Woo1

  • 1Skin&Natural Products Lab, Kolmar Korea Co. Ltd., Seoul, Republic of Korea.

Journal of Cosmetic Dermatology
|July 31, 2025
PubMed
Summary

Visible skin aging like wrinkles and sagging is linked to internal skin changes. Epidermal moisture affects sagging, while dermal elasticity impacts wrinkles, revealing deeper causes of aging.

Keywords:
dermisepidermisexternal skin markersinternal skin markersskin agingskin depth

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Area of Science:

  • Dermatology
  • Aesthetic Science
  • Aging Research

Background:

  • The skin is a complex, multilayered organ.
  • Skin aging is a gradual process, initially internal and later manifesting as visible signs like wrinkles and sagging.

Purpose of the Study:

  • To investigate how changes in different skin layers affect visible aging signs such as wrinkles and sagging.
  • To explore the relationship between internal skin characteristics and external aging indicators.

Main Methods:

  • A study involving 65 Korean women aged 20-65 years.
  • Categorized skin characteristics into visible external markers (wrinkles, sagging) and internal markers (hydration, elasticity, density, thickness, dermal-subcutaneous interface length).
  • Analyzed relationships between age, external, and internal skin parameters using Spearman's correlation.

Main Results:

  • Visible aging signs (wrinkles, sagging) increased with age, while elasticity generally decreased.
  • No correlation was found between skin moisture levels and age.
  • Skin sagging correlated negatively with epidermal moisture, and wrinkles correlated negatively with elasticity in the deeper dermis.

Conclusions:

  • Chronological age strongly correlates with external aging markers.
  • Visible aging is significantly influenced by internal skin layer changes.
  • Epidermal moisture content impacts skin sagging, and dermal elasticity influences wrinkle formation.