Related Experiment Video
Updated: Sep 13, 2025
07:13
Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
Published on: April 12, 2021
4.5K
Drug Usage and Risk for Polypharmacy After Pediatric Solid Organ Transplantation-A National Register Study
Rebekka Salonen1,2, Kira Endén1, Mikael Koskela3
1Department of Pediatric Nephrology and Transplantation, Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Clinical Transplantation
|July 31, 2025
Summary
Young adults who received solid organ transplants (SOT) as children need more chronic medications, especially kidney transplant recipients. This highlights the need for ongoing care to manage long-term health and improve quality of life.
Area of Science:
- Transplantation Medicine
- Pediatric Health
- Pharmacology
Background:
- Solid organ transplant (SOT) recipients face risks of long-term health issues and polypharmacy.
- Pediatric SOT survivors transition to adulthood with potential for chronic conditions.
- Quality of life can be impacted by ongoing medication needs post-transplant.
Purpose of the Study:
- To assess the prevalence of chronic medication use in young adults after pediatric SOT.
- To compare medication needs between different SOT types (kidney, liver, heart).
- To identify specific chronic conditions requiring medication in this population.
Main Methods:
- Study included 215 Finnish individuals who underwent SOT before age 16.
- Data on prescription drug purchases were analyzed from national registries.
- Matched controls (n=1067) were used for comparison.
Main Results:
- SOT recipients averaged 1.53 reimbursed chronic conditions beyond immunosuppression.
- Elevated medication reimbursements were noted for cardiovascular diseases, hormonal deficiencies, and epilepsy compared to controls.
- Kidney transplant recipients showed a higher burden of cardiovascular-related reimbursements than liver recipients.
Conclusions:
- Young adults post-pediatric SOT exhibit an increased requirement for chronic disease medications.
- Kidney transplant recipients face the highest medication burden, liver recipients the lowest.
- Long-term follow-up and tailored transitional care are crucial for managing multimorbidity and enhancing quality of life.
Related Concept Videos
01:21Factors Affecting Drug Response: Overview
2.4K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.4K
01:16Kidney Transplant III: Nursing Management
82
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
82
01:02Prescription, Nonprescription and Orphan Drugs
848
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
848
01:28Kidney Transplant I: Introduction
60
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
60
01:26Kidney Transplant II: Surgical Procedure
76
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
76
01:28Drug Therapy
100
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
100