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The Type of Follicle-Stimulating Hormone Medication Given for In Vitro Fertilization Impacts Oocyte Retrieval: A
Toni J F Michael1, Ranita Kirubakaran2,3, Tanay Parab1
1School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Clinical Pharmacology and Therapeutics
|July 31, 2025
Summary
FSH medication choice impacts retrieved oocytes in IVF, with follitropin alfa yielding more than beta. Ovarian response and hyperstimulation varied, but pregnancy rates were similar across follicle-stimulating hormone (FSH) medications.
Area of Science:
- Reproductive Endocrinology
- In Vitro Fertilization (IVF)
Background:
- Understanding variations in ovarian response to follicle-stimulating hormone (FSH) medications is crucial for optimizing in vitro fertilization (IVF) treatment.
- Different recombinant and urinary FSH preparations exist, each with potential differences in efficacy and safety profiles.
Purpose of the Study:
- To systematically review and compare the number of retrieved oocytes and fertility outcomes following the administration of different FSH medications.
- To analyze the impact of various FSH medications on ovarian response, including oocyte yield and hyperstimulation risk.
Main Methods:
- A systematic review and meta-analysis of studies comparing two or more FSH medications (follitropin alfa, follitropin beta, follitropin delta, urofollitropin).
- Searched databases from inception to November 2024, including 26 studies with 12,613 participants.
- Utilized random effects models with the restricted maximum likelihood method for meta-analyses.
Main Results:
- Follitropin alfa resulted in more retrieved oocytes compared to follitropin beta.
- Follitropin alfa and beta yielded more oocytes than follitropin delta, but with higher total doses and increased hyperstimulation risk.
- Urofollitropin also showed higher oocyte retrieval than follitropin beta, with increased total dosage.
- Variability in ovarian response and hyperstimulation decreased when similar total FSH doses were administered.
Conclusions:
- While FSH medication choice influences oocyte yield and hyperstimulation risk, fertilization, pregnancy, and live birth rates remain comparable.
- Further research is needed to assess oocyte quality across different FSH medications.
- Optimizing FSH dosing may mitigate variability in ovarian response and hyperstimulation.
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